The Conservatives have opened up a 16 point lead on Labour, according to a YouGov survey for the Sunday Times.
Support for Labour fell to 27 per cent - its lowest poll rating since 1983 - with the Conservatives on 43 per cent and the Liberal Democrats on 16 per cent.
David Cameron would have enough for a Commons majority if the results of the Sunday Times survey were repeated in a general election. The Conservatives would have a 120 seat majority in Parliament and a string of high profile cabinet ministers, including John Denham, Secretary of State for Innovation, Universities and Skills, would lose their Commons seats.
Both Southampton seats would turn blue if the national swing was uniform which would also see Alan Whitehead lose his seat.
The poll also found that there has been a slump in Gordon Brown's personal approval, with the -26 rating the lowest since he became prime minister.
Yesterday's ICM poll for the Guardian showed a 13 point lead, with the Conservatives on 42%.